Semen quality impairment is associated with sexual dysfunction according to its severity


By academic.oup.com

Is sexual dysfunction associated with severity of semen quality impairment in men with couple infertility?

SUMMARY ANSWER

In males of infertile couples the prevalence of erectile dysfunction (ED) increases as a function of semen quality impairment severity.

WHAT IS KNOWN ALREADY

Infertile men are at a higher risk for sexual dysfunction, psychopathological and general health disorders. However, it has never been systematically investigated if these problems are associated with severity of semen quality impairment.

STUDY DESIGN, SIZE, DURATION


Cross-sectional analysis of a first-time evaluation of 448 males of infertile couples attending an outpatient clinic from September 2010 to November 2015. In addition, 74 age-matched healthy, fertile men from an ultrasound study on male fertility were studied for comparison.

PARTICIPANTS/MATERIALS, SETTING, METHODS


All subjects underwent a complete physical, biochemical, scrotal and flaccid penile colour-Doppler ultrasound evaluation and semen analysis. Patients had already undergone at least one semen analysis; therefore, the majority were aware of their sperm quality before taking part in the study. Validated tools, such as the International Index of Sexual Function-15 (IIEF-15), Premature Ejaculation Diagnostic Tool (PEDT), Middlesex Hospital Questionnaire (MHQ), National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score and Chronic Disease Score (CDS), were used to evaluate, respectively, sexual dysfunction, premature ejaculation (PE), psychopathological traits, prostatitis-like symptoms, lower urinary tract symptoms and general health status.

MAIN RESULTS AND THE ROLE OF CHANCE


Among men with couple infertility, 96 showed azoospermia (Group #1), 245 at least one sperm abnormality (Group #2) and 107 normozoospermia (Group #3). Fertile men were considered as a control group (Group #4). After adjusting for age, we observed a higher prevalence of ED (IIEF-15-erectile function domain score <26) (18.3% versus 0%; P = 0.006) and PE (PEDT score >8) (12.9% versus 4.1%; P = 0.036) in males of infertile couples compared with fertile men. The ED prevalence increases as a function of semen quality impairment severity (P < 0.0001), even after adjusting for confounders (age, CDS, MHQ and NIH-CPSI total score), despite similar hormonal, glyco-metabolic and penile vascular status. Compared to fertile men, all three groups of males with couple infertility showed a poorer erectile function, associated with an overall psychopathological burden (MHQ total score), particularly with somatized anxiety (MHQ-S).
Azoospermic men showed the worst erectile function and general health: in this group, erectile function was negatively associated not only with psychopathological disturbances (MHQ total and MHQ-S scores; P < 0.0001) but also with a less healthy phenotype (higher CDS; P = 0.015). In addition, azoospermic men reported higher PE prevalence and lower sexual desire and orgasmic function when compared to fertile men (all P < 0.05), all of which were related to psychopathological symptoms.

LIMITATIONS, REASONS FOR CAUTION

The cross-sectional nature of the study represents its main limitation. A possible selection bias concerning the control group of healthy, fertile men recruited into an ultrasound study might have occurred. Finally, causality cannot be inferred in this type of study design and hence there should be some caution in interpreting the results.

WIDER IMPLICATIONS OF THE FINDINGS


Investigation of male sexual function, general health and psychological status in infertile couples, especially if azoospermic, is advisable, in order to improve not only reproductive but also general and sexual health.

Source: https://academic.oup.com/humrep/article-abstract/31/12/2668/2730249/Semen-quality-impairment-is-associated-with-sexual

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Thursday, May 28, 2026

Men's Preventive Health: Screenings That Save Lives

Men are significantly less likely than women to engage in preventive healthcare and are more likely to delay seeking medical attention for concerning symptoms. This behavioral pattern contributes to men being diagnosed with serious conditions at later stages when treatment is less effective. Understanding the preventive health screenings recommended for men and the age ranges at which they apply motivates earlier engagement with preventive care. Blood pressure measurement should be performed at every healthcare visit. Hypertension, the silent killer, affects approximately half of American adults but often produces no symptoms until serious organ damage has occurred. Beginning at age 18, all adults should have their blood pressure checked at least every two years when normal and more frequently when elevated. Lipid screening for cholesterol is recommended for men beginning at age 35 and may be appropriate earlier for men with cardiovascular risk factors or family history. Colorectal cancer screening is recommended for all adults beginning at age 45. Multiple screening methods are available as described in dedicated colorectal screening guidelines. Diabetes screening using fasting glucose or A1C is recommended for all adults aged 35 to 70 who are overweight or obese, and may be appropriate earlier for men with additional risk factors. Abdominal aortic aneurysm one-time screening with ultrasound is recommended for men aged 65 to 75 who have ever smoked. For men identified with conditions requiring prescription medications through preventive screening, pharmacy access is available through https://www.amoxilcompharm.com/. Prostate cancer screening with PSA testing is a subject of ongoing discussion in medical guidelines. Current guidance recommends shared decision-making between patients and providers for men aged 55 to 69, weighing the benefits of early detection against risks of overdiagnosis and overtreatment. Screening is generally not recommended for men 70 and older. Testicular cancer screening involves self-examination and provider examination particularly for men in the high-risk age range of 15 to 35. HIV and STI screening, depression screening, and lung cancer screening for current and former heavy smokers are additional preventive measures for appropriate candidates. For comprehensive men's preventive health information and health resources, visit https://amoxicillina.online/ for accessible and evidence-based patient guidance.

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